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    If you need more than 65536 methods on your application you need to change your Gradle configuration to enable MultiDex and modify your manifest to reference MultiDex class.

Solutions on the web

via GitHub by thestinger
, 1 year ago
No original dex files found for dex location /system/priv-app/DMService/DMService.apk
via Android Enthusiasts by Jörg Wingerath
, 5 months ago
Failed to open dex files from /data/app/com.google.android.syncadapters.contacts-1/base.apk
via xda-developers.com by Unknown author, 1 year ago
No original dex files found for dex location /system/priv-app/SetupWizard/SetupWizard.apk
via GitHub by rom1v
, 1 year ago
No original dex files found for dex location /system/app/Exchange2/Exchange2.apk
via GitHub by ronpf
, 1 year ago
No original dex files found for dex location /data/app/com.hpsj.h2go.droid-1/base.apk
via GitHub by alexrainman
, 1 year ago
No original dex files found for dex location /data/app/com.slbdev.LoadChart.Droid-1/base.apk
java.io.IOException: No original dex files found for dex location /system/priv-app/DMService/DMService.apk	at dalvik.system.DexFile.openDexFileNative(Native Method)	at dalvik.system.DexFile.openDexFile(DexFile.java:295)	at dalvik.system.DexFile.(DexFile.java:80)	at dalvik.system.DexFile.(DexFile.java:59)	at dalvik.system.DexPathList.loadDexFile(DexPathList.java:279)	at dalvik.system.DexPathList.makePathElements(DexPathList.java:248)	at dalvik.system.DexPathList.(DexPathList.java:120)	at dalvik.system.BaseDexClassLoader.(BaseDexClassLoader.java:48)	at dalvik.system.PathClassLoader.(PathClassLoader.java:65)	at android.app.ApplicationLoaders.getClassLoader(ApplicationLoaders.java:58)	at android.app.LoadedApk.getClassLoader(LoadedApk.java:376)	at android.app.LoadedApk.makeApplication(LoadedApk.java:568)	at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4685)