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I/O reactor has been shut down
java.lang.IllegalStateException: I/O reactor has been shut down	at org.apache.http.impl.nio.reactor.DefaultConnectingIOReactor.connect(DefaultConnectingIOReactor.java:164)	at org.apache.synapse.transport.nhttp.HttpCoreNIOSender.sendAsyncRequest(HttpCoreNIOSender.java:285)	at org.apache.synapse.transport.nhttp.HttpCoreNIOSender.invoke(HttpCoreNIOSender.java:208)	at org.apache.axis2.engine.AxisEngine.send(AxisEngine.java:396)	at org.apache.synapse.core.axis2.DynamicAxisOperation$DynamicOperationClient.send(DynamicAxisOperation.java:192)	at org.apache.synapse.core.axis2.DynamicAxisOperation$DynamicOperationClient.executeImpl(DynamicAxisOperation.java:176)	at org.apache.axis2.client.OperationClient.execute(OperationClient.java:163)	at org.apache.synapse.core.axis2.Axis2FlexibleMEPClient.send(Axis2FlexibleMEPClient.java:250)	at org.apache.synapse.core.axis2.Axis2Sender.sendOn(Axis2Sender.java:55)	at org.apache.synapse.core.axis2.Axis2SynapseEnvironment.send(Axis2SynapseEnvironment.java:200)	at org.apache.synapse.endpoints.WSDLEndpoint.send(WSDLEndpoint.java:140)	at org.apache.synapse.mediators.builtin.SendMediator.mediate(SendMediator.java:100)	at org.apache.synapse.mediators.AbstractListMediator.mediate(AbstractListMediator.java:60)	at org.apache.synapse.mediators.filters.InMediator.mediate(InMediator.java:60)	at org.apache.synapse.mediators.AbstractListMediator.mediate(AbstractListMediator.java:60)	at org.apache.synapse.mediators.base.SequenceMediator.mediate(SequenceMediator.java:122)	at org.apache.synapse.core.axis2.Axis2SynapseEnvironment.injectMessage(Axis2SynapseEnvironment.java:154)	at org.apache.synapse.core.axis2.SynapseMessageReceiver.receive(SynapseMessageReceiver.java:89)	at org.apache.axis2.engine.AxisEngine.receive(AxisEngine.java:145)	at org.apache.axis2.transport.http.HTTPTransportUtils.processHTTPPostRequest(HTTPTransportUtils.java:275)	at org.apache.synapse.transport.nhttp.ServerWorker.processPost(ServerWorker.java:218)	at org.apache.synapse.transport.nhttp.ServerWorker.run(ServerWorker.java:182)	at java.util.concurrent.ThreadPoolExecutor$Worker.runTask(ThreadPoolExecutor.java:650)	at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:675)	at java.lang.Thread.run(Thread.java:613)