java.lang.RuntimeException: Connection refused

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java.lang.RuntimeException: Connection refused
at oracle.apps.fnd.wf.mailer.MailerUtils.isSocketConnectableNew(MailerUtils.java:300)
at oracle.apps.fnd.wf.mailer.SMTPUtils.isValidOutbound(SMTPUtils.java:512)
at oracle.apps.fnd.wf.mailer.Mailer.validateParameterValues(Mailer.java:1301)
at oracle.apps.fnd.cp.gsc.SvcComponent.performValidateParameterValues(SvcComponent.java:233)
at oracle.apps.fnd.cp.gsc.SvcComponent.start(SvcComponent.java:314)
at oracle.apps.fnd.cp.gsc.SvcComponentContainer.handleComponentEvent(SvcComponentContainer.java:2223)
at oracle.apps.fnd.cp.gsc.SvcComponentContainer.onBusinessEvent(SvcComponentContainer.java:301)
at oracle.apps.fnd.wf.bes.DispatchThread.run(Unknown Source)

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