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    If you need more than 65536 methods on your application you need to change your Gradle configuration to enable MultiDex and modify your manifest to reference MultiDex class.

Solutions on the web

via Stack Overflow by BryGom
, 1 year ago
Failed to open oat file from dex location '/system/framework/am.jar'
via Stack Overflow by Massy
, 1 year ago
via liudonghua.com by Unknown author, 2 years ago
Failed to open oat file from dex location '/system/framework/services.jar'
via segmentfault.com by Unknown author, 2 years ago
Failed to open oat file from dex location '/system/app/xxxxxxFrameWork/xxxxxxFrameWork.apk'
java.io.IOException: Failed to remove obsolete file from /data/dalvik-cache/arm/system@framework@am.jar@classes.dex when searching for dex file /system/framework/am.jar: Permission denied	at dalvik.system.DexFile.openDexFileNative(Native Method)	at dalvik.system.DexFile.openDexFile(DexFile.java:295)	at dalvik.system.DexFile.(DexFile.java:80)	at dalvik.system.DexFile.(DexFile.java:59)	at dalvik.system.DexPathList.loadDexFile(DexPathList.java:262)	at dalvik.system.DexPathList.makeDexElements(DexPathList.java:231)	at dalvik.system.DexPathList.(DexPathList.java:109)	at dalvik.system.BaseDexClassLoader.(BaseDexClassLoader.java:48)	at dalvik.system.PathClassLoader.(PathClassLoader.java:38)	at java.lang.ClassLoader.createSystemClassLoader(ClassLoader.java:128)	at java.lang.ClassLoader.access$000(ClassLoader.java:65)	at java.lang.ClassLoader$SystemClassLoader.(ClassLoader.java:81)	at java.lang.ClassLoader.getSystemClassLoader(ClassLoader.java:137)